Monday, October 19, 2009

The latest "ESET procedure" reduces the risk of multiple pregnancy

Bleignier Patricia Baker has some pretty fixed ideas about the existence and child-rearing.

Breast is best, education at home is probably the way it will go, and it is not surprising, especially in New Jersey, who was born more of cattle people, to their neighbors in Maryland in rural areas, 5 or 6 miles from Harper's Ferry, W . Virginia

So when Bleignier Baker, 30 years old, I learned that the best option is that the child in vitro fertilization, she knew she wanted to go as natural as possible. For her, it means one child at a time.

"I was going stubborn in the laboratory, I do not want multiples," Bleignier Baker says. "This is a danger to the mother and child."

She delivered her daughter, Dylan, one month before the Birthing Center and her husband, Keith, and daughter, Grasyn, 3, appeared, and returned home several hours later. Baker designed Bleignier Grasyn after a new baby was transferred to the uterus, and the rest were frozen. After three years and one of these embryos are dissolved, were transferred and developed Dylan. Bleignier Baker says she and her husband still has "two" of frozen embryos, and I hope to add to their families in one day.

Of course, Bleignier order multiple pregnancy Baker is in stark contrast to Nadia octuplets Solomon who delivered January 26 galvanized Americans, many of which did not give much thought to the risk of multiple pregnancy, such as prematurity and low birth weight, which can cause health problems at birth, and disability for life.

Photos from Fever, accompanied by eight others fragile Solomon, was born nine weeks early in weights as low as 1 and a half pounds, and looks familiar curious onlookers. In infants, of whom Solomon says came from six embryos, two of which split into twins, and sparked debate about whether the United States follow the lead of Belgium and Sweden, and the laws that limit the number of embryos that doctors can be transferred at a time.

In the laboratory: "October / doctor and my mother is not alone, and many fertility clinics to break the rules
Better Life: an examination of fetuses fuel debate
On the Internet: U.K. Not-for-profit "and one by one," provides more information

Already lawmakers in both states introduced laws to curb transfers of embryos. Missouri would require doctors to follow the American Society for Reproductive Medicine, or ASRM, and guidelines, while Georgia will not go further, restricting women under 40 to two embryos, and those over the age of 40 and three.

Multiple pregnancy on low

Enrichment in the laboratory or in the laboratory, and how it is approximately 1 percent of babies are born in the United States, "says ASRM, infertility major occupational group. In the laboratory, the eggs are removed from the ovaries and mixed with sperm in a petri dish. After several days, resulting in the transfer of the embryo in the uterus or frozen.

For the ASRM, issued guidelines for embryo transfer in first in 1999, the proportion of multiple births continued to rise. Doctors are keen to ensure the success of their patients and encourage them to exercise of the pregnancy rates were excessive embryo transfer. Over the past decade, however, the amount of triple and higher births fell for.

In the ASRM guidelines are based primarily on the patient's age and the quality of the embryo. When women age, and is usually more difficult to conceive their own eggs, so that the number recommended by the increase in transfers from one or two embryos in patients under the age of 35 years, five women and the elderly 40.

According to data in 2007, published online last week by the Society for assisted reproductive technologies, and Michael Kamrava, who said his name as Solomon fertility doctor on the transfer of an average of 4.1 embryos of patients under the age of 35 years - two to four times that, as recommended by the ASRM.

Increasingly, in the laboratory the patients in this age group who are concerned about multiple pregnancy, as Bleignier Baker focused on a relatively new approach: one elective embryo transfer or ESET.

"Five years ago, 10 years, Jenin would not be appropriate at all," said Robert Stilman, medical director of Shady Grove Fertility Center, and medical clinics in Maryland, Virginia and Washington, DC, and this because of the possibility of pregnancy with one embryo is slim.

Reduce the risk of multiple

But thanks to improvements in the cultivation of embryos in the laboratory, and many of the younger patients, doctors can provide an excellent opportunity to visualize and with only one fetus. In the journal Fertility and Sterility in November last year, said that patients ESET Stilman are essentially the same pregnancy rate - 65 per cent - for those who are the transfer of two embryos, but only 1% of patients, ESET twins, compared to 44% of the women who 'd received two embryos.

Karen Cohen is well aware of the risk of complications. Cohen loves his 17 - triplets in the month, by intrauterine insemination, but do not want to go through this again. Therefore, despite the fact that Cohen had conceived in the laboratory, no, she and her husband chose ESET virtually eliminated their ability to obtain more than one child at a time to come.

"It was a very difficult pregnancy," Cohen (33 years), Silver Spring, MD, reminiscent of his first term. I went to work early, 17 weeks and spent 3 and a half months of bed rest before the delivery of triplets at 33 weeks. Although "doing great now," she says, "and encountered some problems in the beginning."

However, the United States fertility patients and their doctors face incentives to move more than the recommended number of embryos. Many patients lack insurance in the laboratory, which costs on average $ 12,500 a session, so they see twins or triplets two or three for the price of one. In most clinics do not, and the transfer of one embryo is likely to lead to the transfer of pregnancy because it is several.

Fertility and infertility in her article, Stilman that patients who suffer from insurance coverage or those in the middle of "risk sharing" program was more likely that the choice of ESET. (Couples in the joint program of the risk of paying a flat $ 20,000 for up to six sessions in the laboratory, and if they do not end up with a baby they will get their money.)

Subscription to the problem

"When we get to the point where covered by insurance, you have a very difficult position," said Barbara Collura, Executive Director of this resolution, a national group of infertility. "You are not desperate."

Limit the transfer of embryos without dealing first with the issue of security will create more shocks and more problems, "said Collura." Let's look at this group the first question. If someone is willing to pay for it, then they are entitled to include the features that. "

In the state of Connecticut, and health plans that include maternity care must be paid for in the lab, but can reduce the number of embryos transferred to two, "said Sean Tipton, spokesman for the American Society for Reproductive Medicine.

In the Netherlands, and there is no strict laws on the number of embryos transferred and said Arno van Peperstraten, a medical Obstetrics / Gynecology at Radboud University Nijmegen, in the e-mail. "However, the government said that over more than two embryos should not be paid to us national health insurance."

Fertility Dutch doctors support the transfer of only one or two embryos, the Peperstraten says, and they are following the case of the United States and octuplets "suspicion."

Solution urges women to consider their health and their child when they discuss the transfer of embryos more than recommended by the ASRM, Collura said.

But, she acknowledges, "it is difficult to reach all of them so that they act in a rational way when they are perhaps the biggest crisis in his life."

Shady Grove Fertility Stilman says every doctor is a laminated paper shows the risk of complications. They review the risks in several places, and begin negotiations with the candidates east all the way to the transfer of embryos.

While the Shady Grove Fertility physicians, ESET support, this is not always the case in other places, "said Stilman. "Most doctors recognize:" Yes, twins complex, but did not accomplish much of the complications that deserves the grounds with my patient, "he said.

One problem is that it is noted that doctors in fertility care provided to patients only when they are pregnant. "We are isolated by reproductive endocrine glands, and we stick on the one hand, and we do not deal with the consequences."

Review of triplets or higher multiples as the failure of the system and focus on a small number of embryo transfer success rates in the calculation of fertility rates may change attitudes of doctors, "said Lawrence Grunfeld professor of obstetrics and gynecology at Mount Sinai School of Medicine in New York.

"In the laboratory, not a way to create triplets," said Grunfeld. "In the laboratory, is a way to avoid triplets."

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